Acute, severe pain due to inflammatory & degenerative form of rheumatism, RA, ankylosing spondylitis, OA. Post-traumatic pain, inflammation & swelling; pain following dental surgery. Acute gout attack.
Hypersensitivity to diclofenac, aspirin or other NSAIDs, Na metabisulphite, benzyl alcohol, propylene glycol, mannitol. History of active or suspected GI ulcers or bleeding; history of haemorrhagic diathesis, confirmed or suspected cerebrovascular bleeding; operations associated w/ high risk of haemorrhage; history of asthma. Hypovolaemia or dehydration. Concomitant use w/ anticoagulant (including low dose heparin). Moderate to severe renal impairment (serum creatinine >160 micromol/L).
Discontinue use at 1st appearance of skin rash or other sign of hypersensitivity or if GI bleeding or ulceration occurs. GI disorders, history of GI ulceration, ulcerative colitis or Crohn's disease; history of serious GI events, smoking, alcoholism. Increased risk of serious CV events eg, MI; patients w/ CV disease or risk of CV event; HTN; fluid retention or heart failure. Exfoliative dermatitis, TEN, SJS. May mask signs & symptoms of infection. Concurrent use of aspirin. Severe hepatic impairment. Not recommended during pregnancy & lactation. Not suitable for childn. Elderly.
Headache, dizziness or vertigo; epigastric pain, other GI disorders; rashes, skin eruptions; serum aminotransferase enzymes elevations; local pain & induration.
Drug Interactions
Hypoglycaemic & hyperglycaemic effects w/ oral antidiabetic agents. Increased risk of haemorrhage w/ anticoagulant therapy. Increased plasma conc of lithium & digoxin. Impaired renal excretion w/ MTX. Nephrotoxicity w/ cyclosporin. Increased risk of GI bleeding w/ aspirin or corticosteroids. Convulsions w/ quinolones. Increased serum K levels w/ K-sparing diuretics. Exacerbated cardiac failure, reduced GFR & increased plasma glycoside levels w/ cardiac glycosides. Decreased effect of antihypertensives eg, β-blockers, ACE inhibitors, diuretics. Reduced mifepristone effect.
M01AB05 - diclofenac ; Belongs to the class of acetic acid derivatives and related substances of non-steroidal antiinflammatory and antirheumatic products.
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